From Heraklion airport drive on the new National Road towards Agios Nikolaos. Follow this road, and at the end of it, left and keep driving until the first  traffic lights. Turn right at the lights and continue on this road driving through Malia.
After Malia turn left at the signpost “Sissi / Vrachasi / Milatos”.  Follow this road for ca. 2,2 km and turn left at the sign for Milatos. After ca. 20 m follow the signs to the left for Sissi. Drive into Sissi and make a right at Domenicana supermarket. After ca. 200 m. Angela Hotel can be seen on the left and right of the street.